352439-37-3
- Product Name：HO-PEG8- NH2
- Molecular Formula：C16H35NO8
- Purity：99%
- Molecular Weight：369.451
Product Details
Purity:99%
Hot Sale Chinese Factory Supply HO-PEG8- NH2 352439-37-3 In Stock
- Molecular Formula:C16H35NO8
- Molecular Weight:369.451
- Boiling Point:464.4±40.0 °C(Predicted)
- PKA:14.36±0.10(Predicted)
- PSA：110.86000
- Density:1.091±0.06 g/cm3(Predicted)
- LogP:-0.24610
352439-37-3 Relevant articles
Supramolecular compound nano-carrier as well as preparation method and application thereof
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Paragraph 0086; 0103, (2021/08/14)
The invention discloses a supramolecular...
PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof
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Paragraph 0024-0026; 0046-0048; 0050, (2020/06/17)
The invention provides a PROTAC compound...
Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand
Kawamura, Shuhei,Ito, Yoshihiko,Hirokawa, Takatsugu,Hikiyama, Eriko,Yamada, Shizuo,Shuto, Satoshi
supporting information, p. 4020 - 4029 (2018/05/07)
We hypothesized that if drug localizatio...
Synthesis of a series of oligo(ethylene glycol)-terminated alkanethiol amides designed to address structure and stability of biosensing interfaces
Svedhem,Hollander,Shi,Konradsson,Liedberg,Svensson
, p. 4494 - 4503 (2007/10/03)
A strategy for the synthesis of a series...
352439-37-3 Process route
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- 352439-36-2
α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene)
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- 352439-37-3
23-amino-3 ,6,9,12,15,18,21-heptaoxatricosan-1-ol
Conditions
| Conditions | Yield |
|---|---|
|
With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 10h; Inert atmosphere;
|
95% |
|
α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene); With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 20h;
With water; In tetrahydrofuran; Further stages.;
|
90% |
-
- 112-60-7
Tetraethylene glycol
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- 352439-37-3
23-amino-3 ,6,9,12,15,18,21-heptaoxatricosan-1-ol
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 4 steps
1.1: pyridine
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: dimethylformamide / 22 h / 20 °C
3.1: 0.51 g / p-TsOH / methanol
4.1: Ph3P / tetrahydrofuran / 20 h / 20 °C
4.2: 90 percent / H2O / tetrahydrofuran
With pyridine; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2.1: Williamson's ether synthesis / 4.1: Staudinger reduction reaction;
|
|
|
Multi-step reaction with 6 steps
1.1: 60 percent / Ag2O / CH2Cl2 / 48 h
2.1: 94 percent / sodium azide / dimethylformamide / 2.5 h / 110 °C
3.1: 92 percent / Et3N / CH2Cl2 / 0.83 h / 0 - 20 °C
4.1: NaH / dimethylformamide / 0.5 h / 20 °C
4.2: dimethylformamide / 22 h / 20 °C
5.1: 0.51 g / p-TsOH / methanol
6.1: Ph3P / tetrahydrofuran / 20 h / 20 °C
6.2: 90 percent / H2O / tetrahydrofuran
With sodium azide; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Williamson's ether synthesis / 6.1: Staudinger reduction reaction;
|
|
|
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; dmap; thionyl chloride / 0 °C
1.2: 0 °C
2.1: potassium iodide; silver(l) oxide / dichloromethane; water / 8 h / 0 - 5 °C
3.1: sodium azide / acetonitrile / 22 h / Inert atmosphere; Reflux
4.1: triphenylphosphine / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere
With dmap; thionyl chloride; sodium azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium iodide; silver(l) oxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
|
352439-37-3 Upstream products
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352439-36-2
α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene)
-
112-60-7
Tetraethylene glycol
-
86770-67-4
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol
-
134179-43-4
11-azide-1-{(methylsulfonyl)oxy}-3,6,9-trioxaundecane
352439-37-3 Downstream products
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1345337-22-5
C21H43NO10
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1358996-28-7
C42H75N3O13
-
1391997-25-3
4-dodecyl-N-[2-(2-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl]-benzamide
Relevant Products
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3-Amino-5-methylisoxazoleCAS：1072-67-9
-
NH2-PEG9- NH2CAS：82209-36-7
-
HO-PEG9- NH2CAS：15332-95-3
