18720-35-9
- Product Name：4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid
- Molecular Formula：C11H16O4
- Purity：99%
- Molecular Weight：212.246
Product Details
pd_meltingpoint:186.0 to 190.0 °C
Purity:99%
Buy Quality 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid 18720-35-9 Fast Shipping
- Molecular Formula:C11H16O4
- Molecular Weight:212.246
- Vapor Pressure:0mmHg at 25°C
- Melting Point:186.0 to 190.0 °C
- Refractive Index:1.551
- Boiling Point:322.473 °C at 760 mmHg
- PKA:4.77±0.10(Predicted)
- Flash Point:122.436 °C
- PSA：63.60000
- Density:1.307 g/cm3
- LogP:1.58460
BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER(Cas 18720-35-9) Usage
|
Uses |
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic Acid has been used as a reactant for the preparation of bicyclo-octyltriazole inhibitors of HSD1 for metabolic syndrome treatment. |
InChI:InChI=1/C11H16O4/c1-15-9(14)11-5-2-10(3-6-11,4-7-11)8(12)13/h2-7H2,1H3,(H,12,13)
18720-35-9 Relevant articles
Bicyclo [2.2.2] octane - 1, 4 - dicarboxylic acid mono methyl ester synthesis method
-
Paragraph 0007; 0024; 0025; 0026; 0027; 0036; 0037, (2017/07/07)
The invention relates to a synthetic met...
POLYMERIZABLE COMPOUND AND OPTICAL ANISOTROPIC BODY
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Paragraph 0202-0204, (2018/01/02)
PROBLEM TO BE SOLVED: To provide a polym...
Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors
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Page/Page column 527; 528, (2016/03/19)
The invention provides compounds of Form...
Design and synthesis of novel 19F-amino acid: A promising 19F NMR label for peptide studies
Bandak, Dmytro,Babii, Oleg,Vasiuta, Roman,Komarov, Igor V.,Mykhailiuk, Pavel K.
supporting information, p. 226 - 229 (2015/03/05)
Novel aliphatic 19F-substituted amino ac...
18720-35-9 Process route
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![dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate](/upload/2024/4/705445cc-fbe9-43b2-8c45-1131689117ec.png)
- 1459-96-7
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
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![1,4-bicyclo[2.2.2]octanedicarboxylic acid](/upload/2024/4/be294695-99ff-4420-920f-16caa8e7fad0.png)
- 711-02-4
1,4-bicyclo[2.2.2]octanedicarboxylic acid
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![bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester](/upload/2024/4/da70b6d4-3361-4dbe-907c-a167552cd422.png)
- 18720-35-9
bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester
| Conditions | Yield |
|---|---|
|
With barium dihydroxide; In methanol; water; for 18h; Ambient temperature;
|
-
- 1459-96-7
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
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- 18720-35-9
bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester
| Conditions | Yield |
|---|---|
|
With potassium hydroxide; In methanol; water; at 90 ℃;
|
95% |
|
With potassium hydroxide; water; In methanol; at -78 - -20 ℃; for 3.75h; Heating / reflux;
|
70% |
|
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate; With potassium hydroxide; water; In methanol; Heating / reflux;
With hydrogenchloride; In water; pH=1 - 2;
|
70% |
|
With water; sodium hydroxide; In methanol; at 20 - 75 ℃; for 16h;
|
58% |
|
With barium hydroxide octahydrate; In methanol; water; at 20 ℃;
|
56% |
|
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate; With water; potassium hydroxide; In methanol; for 24h; Reflux;
With hydrogenchloride; In water; pH=3;
|
55% |
|
With water; sodium hydroxide; In methanol; at 0 - 22 ℃; for 72h;
|
55% |
|
With potassium hydroxide; In methanol; water; at 50 ℃; for 24h;
|
50% |
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With potassium hydroxide; In methanol; water; for 24h;
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44.9% |
|
With potassium hydroxide;
|
|
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dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate; With barium hydroxide; In methanol; water; at 20 - 25 ℃; for 18h;
With hydrogenchloride; In methanol; hexane; water; pH=1 - 2;
|
|
|
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate; With water; potassium hydroxide; In methanol; for 24.5h; Reflux;
With hydrogenchloride; In water; pH=~ 3;
|
|
|
With methanol; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 15.5h;
|
120.4 g |
|
With barium(II) hydroxide; In methanol; water; at 20 ℃; for 12h;
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|
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With lithium hydroxide; In methanol; water; at 20 - 65 ℃; for 6h;
|
|
|
With potassium hydroxide; In methanol; water; for 5h; Reflux;
|
|
|
With sodium hydroxide; In methanol; at 50 ℃; for 5h;
|
5.6 g |
18720-35-9 Upstream products
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94994-15-7
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-
862501-91-5
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-
96102-85-1
4-formyl-bicyclo[2.2.2]octane-1-carboxylic acid
-
959958-69-1
3-(4-(6-amino-2,4-dioxo-1-propyl-3-heptadeuteriopropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-bicyclo[2.2.2]oct-1-yl)propionic acid methyl ester
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